+gt;P1;ACH2_RAT NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-2 CHAIN PRECURSOR. - RATTUS

>P1;ACH2_RAT
NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-2 CHAIN PRECURSOR. - RATTUS NORVEGICUS (RAT).
 M T L S H S A L Q F W T H L Y L W C L L L V P A V L T Q Q G
 S H T H A E D R L F K H L F G G Y N R W A R P V P N T S D V
 V I V R F G L S I A Q L I D V D E K N Q M M T T N V W L K Q
 E W N D Y N V R W D P A E F G N V T S L R V P S E M I W I P
 D I V L Y N N A D G E F A V T H M T K A H L F F T G T V H W
 V P P A I Y K S S C S I D V T F F P F D Q Q N C K M K F G S
 W T Y D K A K I D L E Q M E R T V D L K D Y W E S G E W A I
 I N A T G T Y N S K K Y D C C A E I Y P D V T Y Y F V I R R
 L P L F Y T I N L I I P C L L I S C L T V L V F Y L P S E C
 G E K I T L C I S V L L S L T V F L L L I T E I I P S T S L
 V I P L I G E Y L L F T M I F V T L S I V I T V F V L N V H
 H R S P S T H N M P N W V R V A L L G R V P R W L M M N R P
 L P P M E L H G S P D L K L S P S Y H W L E T N M D A G E R
 E E T E E E E E E E D E N I C V C A G L P D S S M G V L Y G
 H G G L H L R A M E P E T K T P S Q A S E I L L S P Q I Q K
 A L E G V H Y I A D R L R S E D A D S S V K E D W K Y V A M
 V V D R I F L W L F I I V C F L G T I G L F L P P F L A G M
 I *
C;Species: RATTUS NORVEGICUS (RAT).
C;Accession: P12389
R;WADA K., BALLIVET M., BOULTER J., CONNOLLY J., WADA E., DENERIS E.S., SWANSON L.W., HEINEMANN S., and PATRICK J.
SCIENCE 240:330-334(1988).
C;01-OCT-1989 (REL. 12, CREATED)
C;01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE)
C;01-FEB-1991 (REL. 17, LAST ANNOTATION UPDATE)
C;-!- FUNCTION: AFTER BINDING ACETYLCHOLINE, THE ACHR RESPONDS BY AN
C;EXTENSIVE CHANGE IN CONFORMATION THAT AFFECTS ALL SUBUNITS AND
C;LEADS TO OPENING OF AN ION-CONDUCTING CHANNEL ACROSS THE PLASMA
C;MEMBRANE.
C;-!- SUBUNIT: NEURONAL ACHR SEEMS TO BE COMPOSED OF TWO DIFFERENT
C;TYPE OF SUBUNITS: ALPHA AND NON-ALPHA (BETA).
C;EMBL; M20292; RNACHRN1.
C;EMBL; M20293; RNACHRN2.
C;EMBL; M20294; RNACHRN3.
C;EMBL; M20295; RNACHRN4.
C;EMBL; M20296; RNACHRN5.
C;EMBL; M20297; RNACHRN6.
C;PROSITE; PS00236; NEUROTR_ION_CHANNEL.
C;SIGNAL 1 27
C;CHAIN 28 511 ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-2.
C;DOMAIN 28 241 EXTRACELLULAR.
C;TRANSMEM 242 266
C;TRANSMEM 274 292
C;TRANSMEM 308 329
C;DOMAIN 330 484 CYTOPLASMIC.
C;TRANSMEM 485 503
C;DOMAIN 391 402 POLY-GLU.
C;DISULFID 160 174 BY SIMILARITY.
C;DISULFID 224 225 ASSOCIATED WITH RECEPTOR ACTIVATION
C;(BY SIMILARITY).
C;CARBOHYD 56 56 POTENTIAL.
C;CARBOHYD 106 106 POTENTIAL.
C;CARBOHYD 212 212 POTENTIAL.
C;Keywords: POSTSYNAPTIC MEMBRANE; IONIC CHANNEL; GLYCOPROTEIN; SIGNAL; TRANSMEMBRANE; MULTIGENE FAMILY.