ID EGFR_HUMAN AC P00533; P06268; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01

ID   EGFR_HUMAN
AC   P00533; P06268;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-NOV-1991 (REL. 20, LAST ANNOTATION UPDATE)
DE   EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112).
GN   ERBB1 OR EGFR.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RM   84219729
RA   ULLRICH A., COUSSENS L., HAYFLICK J.S., DULL T.J., GRAY A., TAM A.W.,
RA   LEE J., YARDEN Y., LIBERMANN T.A., SCHLESSINGER J., DOWNWARD J.,
RA   MAYES E.L.V., WHITTLE N., WATERFIELD M.D., SEEBURG P.H.;
RL   NATURE 309:418-425(1984).
RN   [2]
RP   SEQUENCE OF 713-924 FROM N.A.
RM   84196372
RA   LIN C.R., CHEN W.S., KRUIGER W., STOLARSKY L.S., WEBER W.,
RA   EVANS R.M., VERMA I.M., GILL G.N., ROSENFELD M.G.;
RL   SCIENCE 224:843-848(1984).
RN   [3]
RP   SEQUENCE OF 150-962 FROM N.A.
RM   84245835
RA   XU Y., ISHII S., CLARK A.J.L., SULLIVAN M., WILSON R.K., MA D.P.,
RA   ROE B.A., MERLINO G.T., PASTAN I.;
RL   NATURE 309:806-810(1984).
RN   [4]
RP   SEQUENCE OF 1028-1210 FROM N.A.
RM   85046483
RA   SIMMEN F.A., GOPE M.L., SCHULZ T.Z., WRIGHT D.A., CARPENTER G.,
RA   O'MALLEY B.W.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 124:125-132(1984).
RN   [5]
RP   SEQUENCE OF 1-29 FROM N.A.
RM   88217333
RA   HALEY J., WHITTLE N., BENNETT P., KINCHINGTON D., ULLRICH A.,
RA   WATERFIELD M.;
RL   ONCOGENE RES. 1:375-396(1987).
RN   [6]
RP   SEQUENCE OF 1-29 FROM N.A.
RA   HALEY J.D., WATERFIELD M.D.;
RL   SUBMITTED (SEP-1990) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN   [7]
RP   RECEPTOR ACTIVITY.
RM   84191554
RA   MROCZKOWSKI B., MOSIG G., COHEN S.;
RL   NATURE 309:270-273(1984).
RN   [8]
RP   PHOSPHORYLATION.
RM   89278137
RA   MARGOLIS B.L., LAX I., KRIS R., DOMBALAGIAN M., HONEGGER A.M.,
RA   HOWK R., GIVOL D., ULLRICH A., SCHLESSINGER J.;
RL   J. BIOL. CHEM. 264:10667-10671(1989).
RN   [9]
RP   REVIEW.
RM   87297456
RA   CARPENTER G.;
RL   ANNU. REV. BIOCHEM. 56:881-914(1987).
CC   -!- FUNCTION: THE EGF RECEPTOR MEDIATES THE BIOLOGICAL SIGNAL OF EGF
CC       AND ALSO OF TRANSFORMING GROWTH FACTOR ALPHA AND VACCINIA VIRUS
CC       GROWTH FACTOR.
CC   -!- BINDING OF EGF TO THE RECEPTOR LEADS TO INTERNALIZATION OF THE
CC       EGF-RECEPTOR COMPLEX, INDUCTION OF THE TYROSINE KINASE ACTIVITY,
CC       STIMULATION OF CELL DNA SYNTHESIS, AND CELL PROLIFERATION.
CC   -!- SIMILARITY: TO THE EGF RECEPTOR FAMILY.
CC   -!- CAUTION: REF. 3 SEQUENCE WAS INCORRECT DUE TO FRAMESHIFTS.
DR   EMBL; X00588; HSEGFPRE.
DR   EMBL; K02047; HSEGFR.
DR   EMBL; K01885; HSEGFRCP.
DR   EMBL; X06370; HSEGFR1.
DR   EMBL; M38425; HSEGFR01.
DR   PIR; A00641; GQHUE.
DR   PIR; A00642; GQHUE2.
DR   PIR; A23062; A23062.
DR   MIM; 131550; NINTH EDITION.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR.
KW   TRANSMEMBRANE; GLYCOPROTEIN; DUPLICATION; RECEPTOR; SIGNAL;
KW   TRANSFERASE; TYROSINE-PROTEIN KINASE; ATP-BINDING; PHOSPHORYLATION.
FT   SIGNAL        1     24
FT   CHAIN        25   1210       EGF RECEPTOR.
FT   DOMAIN       25    645       EXTRACELLULAR.
FT   TRANSMEM    646    668
FT   DOMAIN      669   1210       CYTOPLASMIC (TYROSINE-SPECIFIC PROTEIN
FT                                KINASE ACTIVITY).
FT   REPEAT       75    300       APPROXIMATE.
FT   REPEAT      390    600       APPROXIMATE.
FT   NP_BIND     718    726       ATP (BY SIMILARITY).
FT   BINDING     745    745       ATP (BY SIMILARITY).
FT   MOD_RES     678    678       PHOSPHORYLATION (BY PKC).
FT   MOD_RES    1092   1092       PHOSPHORYLATION (AUTO-).
FT   MOD_RES    1110   1110       PHOSPHORYLATION (AUTO-).
FT   MOD_RES    1172   1172       PHOSPHORYLATION (AUTO-).
FT   MOD_RES    1197   1197       PHOSPHORYLATION (AUTO-, MAJOR SITE).
FT   CARBOHYD    128    128       POTENTIAL.
FT   CARBOHYD    175    175       POTENTIAL.
FT   CARBOHYD    196    196       POTENTIAL.
FT   CARBOHYD    352    352       POTENTIAL.
FT   CARBOHYD    361    361       POTENTIAL.
FT   CARBOHYD    413    413       POTENTIAL.
FT   CARBOHYD    444    444       POTENTIAL.
FT   CARBOHYD    528    528       POTENTIAL.
FT   CARBOHYD    568    568       POTENTIAL.
FT   CARBOHYD    603    603       POTENTIAL.
FT   CARBOHYD    623    623       POTENTIAL.
SQ   SEQUENCE   1210 AA;  134291 MW;  7507159 CN;
     MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV
     VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA
     VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF
     QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC
     TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
     VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK
     NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF
     ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL
     FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCK
     LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM
     GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV
     ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS
     GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI
     CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA
     RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY
     GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK
     FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ
     QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED
     SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN
     TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV
     APQSSEFIGA
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